{"product_id":"geldanamycin-hn71-hn71","title":"Geldanamycin, min. 98 %, for biochemistry, 1 mg, glass","description":"\u003cp\u003eGeldanamycin, min. 98 %, for biochemistry, Molar mass (M) 560,64 g\/mol, Storage temp. -20 °C, CAS No. 30562-34-6, Empirical formula C\u003csub\u003e29\u003c\/sub\u003eH\u003csub\u003e40\u003c\/sub\u003eN\u003csub\u003e2\u003c\/sub\u003eO\u003csub\u003e9\u003c\/sub\u003e\u003c\/p\u003e\n\u003c!-- CARLROTH_PRODUCT_DETAILS_V7 --\u003e\n\u003cdiv class=\"tabbody ProductDetailsComponent\"\u003e\n\u003cdiv class=\"row\" style=\"display:flex; flex-wrap:wrap; width:100%; max-width:100%; margin:10px 0; gap:4px;\"\u003e\n\u003cdiv class=\"col-xs-12 col-md-6\" style=\"flex:0 0 100%; max-width:100%; box-sizing:border-box; margin:10px 0; margin-left:0; \"\u003e\n\n\n\u003c!--superDetailElements --\u003e\n\u003c!-- OtherDetailElements --\u003e\n\u003c!-- Note --\u003e\n\n\n\u003c!-- Base product name --\u003e\n\n\u003c!-- DetailElements --\u003e\n\u003cdiv class=\"item\" style=\"word-wrap:break-word; overflow-wrap:anywhere; hyphens:auto; \"\u003e\n\u003cdiv class=\"details-container\"\u003e\n\n\u003cp style=\"font-size:0.95em; line-height:1.5; margin:12px 0; word-wrap:break-word; overflow-wrap:anywhere; white-space:normal; \"\u003eGeldanamycin arrests cells in G\u003csub\u003e2\u003c\/sub\u003e phase, thus interfering with angiogenesis and oncogenesis. The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of HSP90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis\/cell vitality.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\u003cdiv class=\"item\" style=\"word-wrap:break-word; overflow-wrap:anywhere; hyphens:auto; \"\u003e\n\u003cdiv class=\"details-container\"\u003e\n\n\u003cp style=\"font-size:0.95em; line-height:1.5; margin:12px 0; word-wrap:break-word; overflow-wrap:anywhere; white-space:normal; \"\u003eDue to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\u003cdiv class=\"item\" style=\"word-wrap:break-word; overflow-wrap:anywhere; hyphens:auto; \"\u003e\n\u003cdiv class=\"details-container\"\u003e\n\u003cdiv class=\"paragraph-title\"\u003eDirections for use\u003c\/div\u003e\n\u003cp style=\"font-size:0.95em; line-height:1.5; margin:12px 0; word-wrap:break-word; overflow-wrap:anywhere; white-space:normal; \"\u003eWorking concentration: 1-10 µg\/ml.Photo sensitive! Store protected from light.\u003c\/p\u003e\n\u003c\/div\u003e\n\n\n\u003c\/div\u003e\n\n\n\n\u003c!-- DeliveryText --\u003e\n\n\u003c!-- printCatalogLink --\u003e\n\u003c\/div\u003e\n\n\u003c\/div\u003e\n\u003c\/div\u003e\u003cdiv style=\"margin-top:1.5rem;\"\u003e\n  \u003ca href=\"https:\/\/www.carlroth.com\/medias\/Info-Brochure-ProteaseInhibitors-EN.pdf?context=bWFzdGVyfHRlY2huaWNhbERvY3VtZW50c3wyMzk1MzJ8YXBwbGljYXRpb24vcGRmfGRHVmphRzVwWTJGc1JHOWpkVzFsYm5SekwyZzNPUzlvTlRNdk9URXhOalkwTWpJeE16a3hPQzV3WkdZfDJlNmI4ZGFlNzRjOWZlMGNjMDY2YzZlN2QxNDdjNGE5NmI1OTg5Y2Y0ZjZkZjIyMTI2MzRmN2E2NGE2ODhiZGY\" target=\"_blank\" rel=\"noopener noreferrer\" download style=\"display:inline-flex; align-items:center; gap:.65rem; text-decoration:none; color:#000; font-weight:600; font-size:1rem;\"\u003e\n    \u003csvg style=\"width:1.65rem;height:1.65rem;color:#dc2626;flex-shrink:0;\" viewbox=\"0 0 384 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" aria-hidden=\"true\"\u003e\n      \u003cpath d=\"M64 0C28.7 0 0 28.7 0 64V448c0 35.3 28.7 64 64 64H320c35.3 0 64-28.7 64-64V160H256c-17.7 0-32-14.3-32-32V0H64z\" fill=\"#ffffff\" stroke=\"currentColor\" stroke-width=\"32\"\u003e\u003c\/path\u003e\n      \u003cpath d=\"M256 0V128H384L256 0z\" fill=\"currentColor\"\u003e\u003c\/path\u003e\n      \u003ctext x=\"192\" y=\"380\" font-family=\"Arial, Helvetica, sans-serif\" font-size=\"110\" font-weight=\"bold\" fill=\"currentColor\" text-anchor=\"middle\"\u003ePDF\u003c\/text\u003e\n    \u003c\/svg\u003e\n    Technical Documentation (PDF)\n  \u003c\/a\u003e\n\u003c\/div\u003e","brand":"Carl Roth","offers":[{"title":"1 mg \/ 1 piece","offer_id":56181849194828,"sku":"HN71.1","price":91.95,"currency_code":"EUR","in_stock":true},{"title":"1 mg \/ 6+ pieces","offer_id":56181849227596,"sku":"HN71.1","price":91.95,"currency_code":"EUR","in_stock":true},{"title":"1 mg \/ 24+ pieces","offer_id":56181849260364,"sku":"HN71.1","price":91.95,"currency_code":"EUR","in_stock":true},{"title":"5 mg \/ 1 piece","offer_id":56181849293132,"sku":"HN71.2","price":220.4,"currency_code":"EUR","in_stock":true},{"title":"5 mg \/ 6+ pieces","offer_id":56181849325900,"sku":"HN71.2","price":209.38,"currency_code":"EUR","in_stock":true},{"title":"5 mg \/ 24+ pieces","offer_id":56181849358668,"sku":"HN71.2","price":198.36,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ 1 piece","offer_id":56181849391436,"sku":"HN71.3","price":327.9,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ 6+ pieces","offer_id":56181849424204,"sku":"HN71.3","price":311.51,"currency_code":"EUR","in_stock":true},{"title":"10 mg \/ 24+ pieces","offer_id":56181849456972,"sku":"HN71.3","price":295.11,"currency_code":"EUR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0955\/4827\/7068\/files\/HN71-SF-1000Wx1000H_c082a073-ea47-4c80-87c9-32b12470e5c7.jpg?v=1766478788","url":"https:\/\/www.luminixhealth.com\/en-nl\/products\/geldanamycin-hn71-hn71","provider":"Luminix Health","version":"1.0","type":"link"}