Description
Geneticin disulphate (G418)-solution, 50 mg/ml, BioScience-Grade, sterile, ready-to-use, Molar mass (M) 692,70 g/mol, Density (D) 1 g/cm³, Boiling point (bp) 100 °C, Storage temp. +4 °C, CAS No. 108321-42-2, Empirical formula C20H40N4O10 · 2 H2SO4
Inhibits protein biosynthesis by binding to ribosomes, particularly to eukaryotic 80S ribosomes.Through interference with the tRNA docking process, sequence errors appear and the elongating peptide chain is truncated. Geneticin disulphate unspecifically effects all cells, and is highly toxic for eukaryotic cells. Resistance is mediated by the bacterial enzyme aminoglycoside-3-phosphotransferase.
Extracted from Micromonospora rhodorangea.
Application: Selection of transfected eukaryotic cells.Resistance gene: Neomycin.
| Use | Sterile stock solution, suitable for cell culturing, as well as for biochemical and biomolecular assays. |
Compliance & Safety Information
Danger
Hazard Statements (H-Phrases)
Precautionary Statements (P-Phrases)