Description
Radicicol, min. 98 %, for biochemistry, Molar mass (M) 364,79 g/mol, Storage temp. -20 °C, CAS No. 12772-57-5, UN-Nr. 2811, Empirical formula C18H17ClO6
The strong specific binding of radicicol to heat shock protein 90 (HSP90) leads to deregulation of its target mechanisms: cell cycle, cell proliferation, apoptosis/cell vitality. Also binds to yeast HSP90, E.coli HtpG and TRAP-1. Antifungal effects are probably caused by inactivation of chitin synthase in fungal cells.
Directions for use
Working concentration: 5-300 µM
Compliance & Safety Information
Danger
Hazard Statements (H-Phrases)
H301
Toxic if swallowed
H315
Causes skin irritation
H319
Causes serious eye irritation
H335
May cause respiratory irritation
Precautionary Statements (P-Phrases)
P270
P270 – No description available
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310
P301+P310 – No description available
P302+P352
IF ON SKIN: Wash with plenty of water.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.