Beschreibung
Novobiocin sodium salt, min. 850 µg/mg, for biochemistry, Molar mass (M) 634,62 g/mol, Density (D) 1,42 g/cm³, Storage temp. +4 °C, CAS No. 1476-53-5, EC No. 216-023-6, Empirical formula C31H35N2NaO11
Reduces growth of gram-positive bacteria by inhibition of initiation of DNA-synthesis via binding to ATP-binding sites of gyrase and topoisomerase. Novobiocin also interacts with the C-terminal ATP-binding site of HSP90, hence inhibiting its Chaperon quality.
Also well suited as additive to microbiological nutrient media. Adding 40 mg/l Novobiocin during selective detection of coliform bacteria on Brilliant Green Bile broth (Art. No. CL06.1) efficiently reduces the growth of attendant flora (Alcaide et al., 1982, J. Appl. Bact. 53:143-6).
Working concentration: variable
Compliance & Safety Information
Warnung
Hazard Statements (H-Phrases)
Precautionary Statements (P-Phrases)