Beschrijving
N₄-Benzoyl-2'-deoxy-5'-O-DMT-2',2'-difluorocytidine-3'-CE-fosforamidiet is een gefluoreerde cytidine-bouwsteen voor de synthese van gespecialiseerde oligonucleotiden. Geregistreerd onder CAS-nummer 142808-44-4, bezit het de brutoformule C₄₆H₅₀F₂N₅O₈P en een molaire massa van 869,89 g/mol. De 2',2'-difluormodificatie op de suiker, gecombineerd met N₄-benzoylprotectie, 5'-O-DMT en een 3'-cyaanethylfosforamidiet, maakt gecontroleerde introductie van residuen van het gemcitabine-type in DNA-strengen mogelijk. De welgedefinieerde structuur ondersteunt reproduceerbare koppeling in de fosforamidietchemie. Laboratoria die geavanceerde probes of medicinale oligonucleotiden ontwikkelen, kunnen dit amidiet inzetten binnen vastgestelde vaste-faseprotocollen. Het materiaal maakt deel uit van de selectie biochemicaliën voor toepassingen in nucleïnezuursynthese.
Dit artikel hoort bij Co-enzymen, nucleotiden & vitaminen, in Biochemicaliën & reagentia.
Belangrijkste kenmerken
- Zuiverheid (HPLC): ≥ 95 %
- Kleur: wit tot gebroken wit
- Vorm: poeder
- CAS-nummer: 142808-44-4
- Verpakkingsgrootten: 25 mg, 50 mg, 100 mg
- Brutoformule: C₄₆H₅₀F₂N₅O₈P
- Molaire massa: 869,89 g/mol
- Producttype: 3'-CE-fosforamidiet
- Technisch informatieblad:
- Veiligheidsinformatieblad:
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