Description
5'-O-DMT-2'-O-methyluridine 3'-CE phosphoramidite is a standard 2'-O-methyl RNA phosphoramidite used in solid-phase oligonucleotide synthesis. It is registered under CAS number 110764-79-9 with the empirical formula C₄₀H₄₉N₄O₉P and a molar mass of 760,83 g/mol. The molecule features 5'-O-dimethoxytrityl protection, a 2'-O-methyl modification on the uridine sugar, and a 3'-cyanoethyl phosphoramidite group for conventional coupling cycles. Applications include antisense and siRNA research, aptamer engineering, and diagnostic probe construction where 2'-O-methyl uridine residues are specified. Maintain anhydrous handling typical of phosphoramidite reagents to ensure reliable coupling efficiency on automated synthesizers and in manual protocols.
This article is part of Coenzymes, nucleotides & vitamins, in Biochemicals & reagents.
Key features
- Purity (HPLC): ≥ 98 %
- Colour: white to off-white
- Form: powder
- ¹H-NMR Spectrum: corresponds to assigned structure
- Water content (KF): ≤ 0.2 %
- CAS number: 110764-79-9
- Pack sizes: 2 g, 5 g, 10 g, 25 g
- Empirical formula: C₄₀H₄₉N₄O₉P
- Molar mass: 760,83 g/mol
- Chemical class: 2'-O-Methyluridine 3'-CE phosphoramidite
- Protection: 5'-O-DMT, 2'-O-methyl
- Technical Information Sheet:
- Safety Data Sheet:
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