Description
Pefabloc® SC-Protease Inhibitor, min. 95 %, for biochemistry, Molar mass (M) 239,7 g/mol, Storage temp. +4 °C, CAS No. 30827-99-7, UN-Nr. 3261, Empirical formula C8H10NSO2F · HCl
Broadband inhibitor for serine proteases. Reacts covalently with the serin of the active center. Alternative to PMSF and DFP with a great number of advantages to standard inhibitors.
- Extremely low toxicity (LD50 >2800 mg/kg)
- Stability in neutral range
- High solubility in aqueous buffers
- Wide spectrum of specifity for serin protease
- Minimal reaction to cell growth
Directions for use
Working concentration: 1-5 mM.Pefabloc® reacts with thiols. DTT and β-mercaptoethanol reduce the inhibitory effect.
Compliance & Safety Information
Danger
Hazard Statements (H-Phrases)
H314
Causes severe skin burns and eye damage
Precautionary Statements (P-Phrases)
P280
Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water [or shower].
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P310
Immediately call a POISON CENTER/doctor.