Description
Geldanamycin, min. 98 %, for biochemistry, Molar mass (M) 560,64 g/mol, Storage temp. -20 °C, CAS No. 30562-34-6, Empirical formula C29H40N2O9
Geldanamycin arrests cells in G2 phase, thus interfering with angiogenesis and oncogenesis. The specific binding of geldanamycin to heat shock protein 90 (HSP90) and its ER homologue GP96 leads to inhibition of the chaperone, results in degradation of HSP90 substrates and, subsequently, to deregulation of central cell mechanisms - cell cycle, cell proliferation, apoptosis/cell vitality.
Due to its antitumor potential it may be used as antibiotic against several eucaryotic carcinogenic cell lines. Additionally, geldanamycin is used as inhibitor of tyrosin-kinase and during analysis of several other physiological regulatory mechanisms.
Working concentration: 1-10 µg/ml.Photo sensitive! Store protected from light.
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Geldanamycin, min. 98 %, for biochemistry, 1 mg, glass is the article on this page. Luminix Health distributes Carl Roth for laboratory use. It sits in Protein biology (other), inside Protein biology & Western blot, in Life Science & Microbiology.
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