Description
EC 4/3 NUCLEOSIL 100-5 C18 HD is an HPLC guard column developed to shield analytical main columns in reversed-phase liquid chromatography. It has a length of 4 mm and an internal diameter of 3 mm, and is filled with NUCLEOSIL 100-5 C18 HD stationary phase for high-density C18 selectivity. Positioned ahead of the analytical column, the guard cartridge traps particulates and strongly retained matrix components, helping maintain efficiency, retention stability and overall column service life. The product is supplied as a pack of 3 pieces and suits main columns with 3, 4 or 4,6 mm internal diameter when used with the Column Protection System guard column holder (REF 718966). Offered by manufacturer Macherey-Nagel, these EC 4/3 NUCLEOSIL C18 HD guard columns align with matching analytical phases for pharmaceutical QC, environmental analysis and research HPLC methods, providing a straightforward way to protect system performance and reduce unplanned column changeovers.
This article is part of HPLC columns, in HPLC columns & accessories.
Key features
- Pack size: 3 pc(s)
- Product type: HPLC guard column
- Stationary phase: NUCLEOSIL 100-5 C18 HD
- Length: 4 mm
- Internal diameter: 3 mm
- EAN: 4046681081408
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Questions about EC 4/3 NUCLEOSIL 100-5 C18 HD
What is this article?
EC 4/3 NUCLEOSIL 100-5 C18 HD is the article on this page. Luminix Health distributes Macherey-Nagel for laboratory use. It sits in HPLC guard columns, inside HPLC columns & accessories, in Chromatography equipment.
A guard column is a short column of the same phase as the analytical column, placed in front of it to catch particles and compounds that would stick forever. It is meant to be replaced. A guard of a different phase changes the separation. The holder and the cartridge are often separate parts.
An HPLC column is a tube packed, or coated, with a stationary phase. The sample is carried through it by a liquid, and the compounds leave at different times. The phase, the particle size, the length and the internal diameter decide the separation. A guard column is a short sacrificial piece in front of the analytical column. Fittings and tubing have a bore that either preserves the peak or smears it. Compound names follow IUPAC. Data are on PubChem. Method grades often cite the European Pharmacopoeia or USP.
Which category should I open next?
The category is HPLC columns & accessories. The sub-category is HPLC guard columns. The catalogue is Chromatography equipment.
Shelves beside this one are HPLC columns, HPLC fittings, tubing & inline filters and HPLC accessories.
What should I check before I order?
When this page shows a safety data sheet, use that manufacturer file. Hazard text does not belong in the sales description. For a pack size, a grade or a certificate that is not on the page, send a quote request or contact the team.
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Luminix Health distributes this article from the heart of Europe. Articles in stock ship within 2–5 business days. Standard delivery is free from €250 excl. VAT. Cold-chain goods and dangerous goods under ADR are never included in that free delivery. The terms are in the Shipping Policy. The full brand index is on shop by brand. Who we are is on about us.
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The seven catalogues are Labware, Lab chemicals, Lab instruments, Lab consumables, Chromatography equipment, Lab safety equipment and Life Science & Microbiology.

